Hybrid oligonucleotide phosphorothioates

Details Hybrid oligonucleotide phosphorothioates Hybrid oligonucleotide phosphorothioates

2006-05-16

2006-05-16

Riley, Jezia (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C435S006120

Reexamination Certificate

active

07045609

ABSTRACT:
The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2′-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.

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