Hybrid oligonucleotide phosphorothioates

Details Hybrid oligonucleotide phosphorothioates Hybrid oligonucleotide phosphorothioates

1995-06-07

2000-11-07

Riley, Jezia

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 44, 536 231, 536 253, 536 2533, 536 257, 424601, C07H 2104, A01N 4304, A01N 5926

Patent

active

061438812

ABSTRACT:
The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2'-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.

REFERENCES:
patent: 4689320 (1987-08-01), Kaji
patent: 4806463 (1989-02-01), Goodchild et al.
patent: 4908307 (1990-03-01), Rodland et al.
patent: 5013830 (1991-05-01), Ohtsuka et al.
patent: 5015570 (1991-05-01), Scangos et al.
patent: 5107065 (1992-04-01), Shewmaker et al.
patent: 5134066 (1992-07-01), Rogers et al.
patent: 5149797 (1992-09-01), Pederson et al.
patent: 5149798 (1992-09-01), Agrawal et al.
patent: 5194428 (1993-03-01), Agrawal et al.
patent: 5220007 (1993-06-01), Pederson et al.
patent: 5478369 (1995-12-01), Albertsen et al.
patent: 5591721 (1997-01-01), Agrawal et al.
patent: 5652355 (1997-07-01), Metelev et al.
Uhlmann et al. "Antisense Oligonucleotides: A New Therapeutic Principle" Chemical Reviews, vol. 90, No. 4, pp. 543-584, Jun. 1990.
Shibahara et al. "Site-Directed cleavage of RNA" Nucleic Acids Research, vol. 15, pp. 4403-4415, 1987.
Agrawal and Tang, Tetrahedron Lett. 31, 1543-1546 (1990).
Agrawal et al. Proc. Natl. Acad. Sci USA 85, 7079-7083 (1988).
Agrawal et al., Biochem. Pharmacol. 50 (4), 571-576 (1995).
Agrawal et al., Nucleosides & Nucleotides 8, 819-823 (1989).
Agrawal et al., Proc. Natl. Acad. Sci USA 86, 7790-7794 (1989).
Agrawal et al., Proc. Natl. Acad. Sci USA 87, 1401-1405 (1990).
Agrawal, Tibtech 10, 152-158 (1992).
Agris et al., Biochem 25, 6268-6275 (1986).
Atabekov et al., FEBS Lett. 232, 96-98 (1988).
Birg et al., Nucleic Acids Res. 18, 2901-2908 (1990).
Brill et al., J. Amer. Chem. Soc. 113, 3972-3980 (1991).
Campbell et al., Nature 311, 350-355 (1984).
Cooney, Science, vol. 241, pp. 456-459, Jul. 22, 1988.
Dagle et al., Antisense Res. Dev. 1, 11-20 (1991).
Dagle et al., Nucleic Acids Res. 18, 4751-4757 (1990).
Dagle et al., Nucleic Acids Res. 19, 1805-1810 (1991).
Davison and Scott, J. Gen. Virol. 67, 2279-2286 (1986).
Eder and Walder, J. Biol. Chem. 266, 6472-3479 (1991).
Furdon et al., Nucleic Acids Res. 17, 9193-9204 (1989).
Gao et al., Antimicrob. Agents and Chem. 34, 808-812 (1990).
Harris et al., J. Virol 36, 659-664 (1980).
Helene et al., Biochimie 67, 777-783 (1985).
Holt et al., Molecular & Cell Biology 8(2), 963-973 (Feb. '88).
Inoue et a., Nucleic Acids Res. 15, 6131-6149 (1987).
Inoue et al., FEBS Lett. 215(2), 327-330 (1987).
Inoue et al., Nucleic Acids Res. 16, 165-168 (1985).
James, Antiviral Chemistry & Chemotherapy, vol. 2 #4, pp. 191-214 (1991).
Kastner et al., The EMBO Journal 9(5), 1603-1614 (1990).
Kawasaki et al., "Synthesis and Biophysical Studies of 2'-dRIBO-2'-F Modified Oligonucleotides," Scientific Conference in Florida, U.S.A. in Jan., 1991.
Kawasaki et al., J. Med. Chem. 36, 831-841 (1993).
Kibler-Herzog et al., Nucleic Acids Res. 19, 2979-2986 (1991).
Leiter et al., Proc. Natl. Acad. Sci USA 87, 3430-3434 (1990).
Marshall et al., Science 259, 1564-1570 (1993).
Miller and Ts'O, Annual Reports of Medicinal Chemistry 23, 295-304 (1988).
Miller and Ts'O, Anti-Cancer Drug Design 2, 117-128 (1987).
Monia et al., J. Biol Chem. 268(19), 14514-14522 (1993).
Oligodeoxynucleotides: Antisense Inhibitors of Gene Expression (J.S. Cohen, ed., CRC Press, Boca Raton, 1989).
Paterson et al., Proc. Natl. Acad. Sci. USA 74, 4370-4374 (1987).
Petersen and Neilsen, Tetrahedron Letters 31, 911-914 (1990).
Quartin et al., Biochemistry 28, 1040-1047 (1989).
Quartin et al., Nucleic Acids Res. 17(18), 7253-7262 (1989).
Rice et al., Science 229, 726-733 (1985).
Richards et al., Virol. 89, 395-408 (1978).
Robertson et al, J. Virol, 54, 651-660 (1985).
Saison-Behmoaras et al., EMBO Journal 10, 1111-1118 (1991).
Sarin et al., Proc. Natl. Acad. Sci USA 85, 7448-7451 (1988).
Shibabara et al., Nuc. Acids. Res., vol. 17, No. 1, pp. 239-252 (1989).
Shibabara et al., Nucleic Acids Research 15 (11), 4403-4415 (1987).
Sitruk-Ware et al., Contraception 41(3), 221-243 (1990).
Stahl and Prusiner, FASEB J. 5, 2799-2807 (1991).
Stein et al., Science 261, 1004-1012 (1993).
Storey et al., Nucleic Acids Res. 19, 4109-4114 (1991).
Tidd et al., Anticancer Res. 10, 1169-1182 (1990).
Tidd et al., British J. of Cancer 60, 343-350 (1989).
Tseng et al., Cancer Gene Therapy 1(1), 65-71 (1994).
Uhlman et al., Chemical Reviews 90(4), 543-584 (1990).
Uhlman et al., Chemical Reviews 90(4), 543-584 (1990).
Verspieren et al., Gene 61, 307-315 (1987).
Weiss, Science News 139, 108-109, Feb. 16, 1991.
Westermann et al., Biomed. Biochem. Acta 48, 85-93 (1984).
Wickstrom et al., The FASEB Journal 5(5), A1443 (1991).
Wickstrom, J. Biochem. Biophys. Meth. 13, 97-102 (1986).
Wickstrom, Tibetch 10, 281-287 (1992).
Zamecnik and Stephenson, Proc. Natl. Acad. Sci USA 75, 280-284 (1978).
Zhang et al., Biochemical Pharmacology 50, 545-556 (1995).
Zurita et al., Proc. Natl. Acad. Sci USA 84, 2340-2344 (1987).

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