Hybrid oligonucleotide phosphorothioates

Details Hybrid oligonucleotide phosphorothioates Hybrid oligonucleotide phosphorothioates

1992-07-23

1997-07-29

Rories, Charles C. P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 243, 536 2431, 536 2432, 435 6, C07H 2100, C07H 2102, A61K 3170, C12Q 168

Patent

active

056523556

ABSTRACT:
The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonueleosides or 2'-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.

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