Hybrid monoclonal antibodies, their production and use

Details Hybrid monoclonal antibodies, their production and use Hybrid monoclonal antibodies, their production and use

1994-12-29

1996-04-09

Feisee, Lila

Chemistry: molecular biology and microbiology

Spore forming or isolating process

5303733, 5303871, 5303913, 53038825, 53038826, C12N 518, C07K 1646, C07K 1636, C07K 1640

Patent

active

055061354

ABSTRACT:
The present invention provides a hybrid monoclonal antibody having specificities against fibrin and thrombolytic substance, a polydoma which produces said antibody and thrombolytic agent comprising said antibody and thrombolytic substance which is immunologically coupled thereto, and methods of using said antibody in combination with thrombolytic substance for lysis or removal of thrombi.

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patent: 4714681 (1987-12-01), Reading
patent: 4916070 (1990-04-01), Matsueda et al.
Molecular Immunology, 20, 521 (1983).
Proc. Natl. Acad. Sci. USA, 84, 7659 (1987).
Science, 229, 765 (1985), Bode et al.
Mountain et al. Biotechnology and Genetic Engineering Reviews. pp. 10-13 1992.
Goding. Monoclonal Antibodies Principles and Practice. 1986, p. 124.
Hird et al. Genes and Cancer 1990 p. 184.
Waldmann Science vol. 252:1657 1991.
PNAS Salemo et al. 81(1) 110-4 1984 (abstract).
Collen et al. Annu. Rev. med. 39 405-23 1988 (abstract).

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