Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1995-10-25
1999-10-12
Campell, Bruce R.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424422, 435382, 935 59, 935 62, A01N 6300, A61K 4800, A61F 1300, C12N 500
Patent
active
059651253
ABSTRACT:
An implantable device having a body of matrix material made up of insoluble collagen fibrils, and disposed therewithin
REFERENCES:
patent: 4485096 (1984-11-01), Bell
patent: 4604346 (1986-08-01), Bell et al.
patent: 4686098 (1987-08-01), Kopchick et al.
patent: 4837379 (1989-06-01), Weinberg
patent: 4861714 (1989-08-01), Dean et al.
patent: 4863856 (1989-09-01), Dean, Jr. et al.
patent: 4963489 (1990-10-01), Naughton et al.
patent: 4997753 (1991-03-01), Dean, Jr. et al.
patent: 5032508 (1991-07-01), Naughton et al.
patent: 5100783 (1992-03-01), Dean, Jr. et al.
patent: 5266480 (1993-11-01), Naughton et al.
patent: 5270192 (1993-12-01), Li et al.
Sullivan et al., "Biohybrid Artificial Pancreas: Long-Term Implantation Studies in Diabetic, Pancreatectomized Dogs", Science 252:718-721, May 3, 1991.
Bell et al., Production of a Tissue-like Structure by Contraction of Collagen Lattices by Human Fibroblasts of Different Proliferative Potential In Vitro, Proc. Natl. Acad. Sci. USA 76:1274-1278, 1979.
Bell et al., Recipes for Reconstituting Skin, J. Biomechanical Engineering 113:113-119, 1991.
Bergsteindottir et al., The Effect of Three Dimensional Collagen Type I Preparation on the Structural Organization of Guinea Pig Enteric Ganglia in Culture, Experimental Cell Research 209:64-75, 1983.
Bisbee et al., Mouse Mammary Epithelial Cells on Floating Collagen Gels: Transepithelial Ion Transport and Effects of Prolactin, Proc. Natl. Acad. Sci. USA 76:536-540, 1979.
Boyce et al., Biologic Attachment, Growth, and Differentiation of Cultured Human Epidermal Keratinocytes on a Graftable Collagen and Chondroitin-6-Sulfate Substrate, Surgery 103:421-430, 1988.
Demetriou et al., Replacement of Liver Function in Rats by Transplantation of Microcarrier-Attached Hepatocytes, Science 233:1190-1192, 1986.
Elsdale and Bard, Collagen Substrata for Studies on Cell Behavior, J. Cell Biology 54:626-627, 1972.
Emerman and Pitelka, Maintenance and Induction of Morphological Differentiation in Dissociated Mammary Epithelium on Floating collagen Membranes, In Vitro 13:316-328, 1977.
Gilbert et al., Cell Transplantation of Genetically Altered Cells on Biodegradable Polymer Scaffolds in Syngeneic Rats, Transplantation 56:423-427, 1993.
Halberstadt et al., The In Vitro Growth of a Three-Dimensional Human Dermal Replacement Using a Single-Pass Perfusion System, Biotechnology and Bioengineering 43:740-746, 1994.
Kleinman et al., Role of Collagenous Matrices in the Adhesion and Growth of Cells, J. Cell Biology 88:473-485, 1981.
Krueger et al., Genetically Modified Skin to Treat Disease: Potential and Limitations, J. Investigative Dermatology, 103:76S-84S, 1994.
Moullier et al., Long-term Delivery of a Lysosomal Enzyme by Genetically Modified Fibroblasts in Dogs, Nature Medicine, 1995.
Moullier et al., Correction of Lysosomal Storage in the Liver and Spleen of MPS VII Mice by Implantation of Genetically Modified Skin Fibroblasts, Nature Genetics 4:154:159, 1993.
Moullier et al., Continuous Systemic Secretion of a Lysosomal Enzyme by Genetically Modified Mouse Skin Fibroblasts, Transplantation 56:427-432, 1993.
Nakagawa et al., Long-term Culture of Fibroblasts in Contracted Collagen Gels: Effects on Cells Growth and Biosynthetic Activity, J. Investigative Dermatology 93:792-798, 1989.
Palmer et al., Genetically Modified Skin Fibroblasts Persist Long After Transplantation but Gradually Inactivate Introduced Genes, Proc. Natl. Acad. Sci. USA 88:1330-1334, 1991.
Palmer et al., Production of Human Factor IX in Animals by Genetically Modified Skin Fibroblasts: Potential Therapy for Hemophilia B, Blood 73:438-445, 1989.
Reuveny, Microcarriers in Cell Culture: Structure and Applications, Advances in Cell Culture 4:213-47, 1985.
Shahar et al., Cerebral Neurons, Skeletal Myoblasts, and Cardiac Muscle Cells Cultured on Macroporous Beads, Biotechnology and Bioengineering 43:826-831, 1994.
Turley et al., The Retention and Ultrastructural Appearances of Various Extracellular Matrix Molecules Incorporated into Three-Dimensional Hydrated Collagen Lattices, Developmental Biology 109:347-369, 1985.
Varani et al., Cell Growth on Microcarriers: Comparison of Proliferation on and Recovery from Various Substrates J. Biological Standardization 14:331-336, 1986.
Vournakis and Runstadler, Microenvironment: The Key to Improved Cell Culture Products, Bio/Technology 7:143-145, 1989.
Weinberg and Bell, Regulation of Proliferation of Bovine Aortic Endothelial Cells, Smooth Muscle Cells, and Adventitial Fibroblasts in Collagen Lattices, J. Cellular Physiology 122:410-414, 1985.
Campell Bruce R.
Transkaryotic Therapies Inc.
LandOfFree
Hybrid matrix implants and explants does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hybrid matrix implants and explants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hybrid matrix implants and explants will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-649376