Hybrid interferon &tgr;/type I interferon polypeptides

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.

Reexamination Certificate

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C435S069510, C435S069700, C424S085400, C424S085700, C424S085600

Reexamination Certificate

active

06174996

ABSTRACT:

Patent application Ser. No. 08/139,8915 was incorporated by reference into application Ser. No. 08/438,753 (now U.S. Pat. No. 5,705,363), which was incorporated by reference into application Ser. No. 08/455,021 (now U.S. Pat. No. 5,958,402), which is incorporated by reference herein. Portions of the 08/139,891 application which were incorporated by reference into the intervening applications, and thus into the present application, are specifically included herein.
FIELD OF THE INVENTION
The present invention relates to interferon-&tgr; compositions and methods of use.
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BACKGROUND OF THE INVENTION
Conceptus membranes, or trophectoderm, of various mammals produce biochemical signals that allow for the establishment and maintenance of pregnancy (Bazer, et al., 1983). One such protein, ovine trophoblast protein-one (oTP-1), was identified as a low molecular weight protein secreted by sheep conceptuses between days 10 and 21 of pregnancy (Wilson, et al., 1979; Bazer, et al., 1986). The protein oTP-1 was shown to inhibit uterine secretion of pr

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