Hybrid human leukocyte interferons

Details Hybrid human leukocyte interferons Hybrid human leukocyte interferons

1981-02-23

1983-11-08

Tanenholtz, Alvin E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112R, 435 68, 435 70, C07C10352, C07G 700, C12P 2100, C12P 2106

Patent

active

044141505

ABSTRACT:
Disclosed herein are methods and means of microbially preparing novel human hybrid leukocyte interferons, useful in the treatment of viral and neoplastic diseases, by DNA recombination of parental interferon genes, taking advantage of common restriction endonuclease cleavage sites therein and in carrier expression plasmids.

REFERENCES:
patent: 4262090 (1981-04-01), Colby et al.
Derynck et al., Nature 285, 542 (1980).
Nagata et al., Nature 284, 316 (1980).
Taniguchi et al., Proc. Japan. Acad. Sci. Ser B 55, 464 (1979).
Research Disclosure, Jul. 1979, pp. 351-352.
Nienhuis et al., New Eng. J. Med. 297, 1318 (1977).
Miozzari et al., Nature 277, 486 (1979).
Itakura et al., Science 196, 1056 (1977).

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