Hybrid human leukocyte interferons

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of...

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435 68, 435 70, 435 71, 435 91, 4351723, 435240, 435241, 435253, 435317, 435811, 435840, 435849, 536 27, 935 10, 935 29, 935 38, 935 72, 935 73, C12N 100, C12N 1500, C12N 500, C12N 502, C12N 120, C12P 2100, C12P 2102, C12P 2104, C12P 1934, C12R 113, C12R 119, C07H 2104

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active

046787518

ABSTRACT:
Disclosed herein are methods and means of microbially preparing novel human hybrid leukocyte interferons, useful in the treatment of viral and neoplastic diseases, by DNA recombination of parental interferon genes, taking advantage of common restriction endonuclease cleavage sites therein and in carrier expression plasmids.

REFERENCES:
patent: 4414150 (1983-11-01), Goeddel
patent: 4456748 (1984-06-01), Goeddel
Goeddel et al., "Human Leukocyte Interferon Produced by E. Coli is Biologically Active", Nature 287: 411 (1980).

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