Hybrid hepatocyte growth factor gene having high expression...

Details Hybrid hepatocyte growth factor gene having high expression... Hybrid hepatocyte growth factor gene having high expression...

2004-09-20

2010-10-12

Nashed, Nashaat T (Department: 1656)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100, C435S325000, C435S252300, C435S252330, C435S254200, C435S069100, C435S069400, C435S070100, C435S071100, C514S04400A

Reexamination Certificate

active

07812146

ABSTRACT:
The present invention relates to a hybrid Hepatocyte Growth Factor (HGF) gene which is prepared by inserting an inherent or foreign intron between exons 4 and 5 in HGF cDNA, which has a base sequence of SEQ ID NO: 2. The gene has high expression efficiency and simultaneously expresses two heterotypes of HGF and dHGF (deleted variant HGF). Further the gene may be used for treating or preventing ischemic or liver diseases.

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