Hybrid hepatocyte growth factor gene having high expression...

Details Hybrid hepatocyte growth factor gene having high expression... Hybrid hepatocyte growth factor gene having high expression...

2007-12-14

2010-11-23

Bertoglio, Valarie (Department: 1632)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S320100, C435S325000, C435S252300, C435S252330, C435S254200, C435S069100, C435S069400, C435S070100, C435S071100, C536S023510

Reexamination Certificate

active

07838505

ABSTRACT:
The present invention relates to a hybrid Hepatocyte Growth Factor (HGF) gene which is prepared by inserting an inherent or foreign intron between exons 4 and 5 in HGF cDNA, which has a base sequence of SEQ ID NO: 2. The gene has high expression efficiency and simultaneously expresses two heterotypes of HGF and dHGF (deleted variant HGF). Further the gene may be used for treating or preventing ischemic or liver diseases.

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