Hybrid DNA synthesis of insulin

Details Hybrid DNA synthesis of insulin Hybrid DNA synthesis of insulin

1990-02-13

1991-05-14

Teskin, Robin L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

4351723, 4353201, 435255, 435256, 435 694, 435 698, 435 699, 435 691, 536 27, 935 47, 935 48, 935 49, 935 11, C12N 1500, C12N 200, C12P 2102, C12P 2100

Patent

active

050155750

ABSTRACT:
Methods and compositions are provided for efficient production of polypeptides having insulin activity. The proinsulin gene is joined to secretion and processing signals for expression and secretion in yeast. The product may be obtained in enhanced yield in the nutrient medium.
Cell line pyinse was deposited at the A.T.C.C. on Apr. 6, 1983 and given Accession No. 20670.

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Thorner, (1981) Mol. Biol. of the Yeast Saccharomyces: Life Cycle and Inheritance, Strathern et al., eds., Cold Spring Harbor, pp. 161-163.
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Villa-Komaroff et al., (1978) 75(8):3727-3731.
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