Hybrid DNA synthesis of epidermal growth factor

Details Hybrid DNA synthesis of epidermal growth factor Hybrid DNA synthesis of epidermal growth factor

1987-06-03

1988-11-08

Martinell, James

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 70, 435 91, 4351721, 4351723, 435253, 435255, 435320, 536 27, 935 13, 935 69, 935 70, 935 72, C12N 500, C12N 1500, C12P 2102, C12P 1934

Patent

active

047834129

ABSTRACT:
DNA sequences and methods of obtaining DNA sequences which include a sequence encoding for mammalian epidermal growth factor are provided. The DNA sequences may be used in cloning and expression vectors for production of DNA and RNA and for producing polypeptides including mammalian epidermal growth factor.
E. coli strains HB 101 (pmegf1) and HB 101 (pmegf10b), and bacteriophage .lambda.hEGF34 were deposited at the A.T.C.C. on May 10, 1983 and given Accession Nos. 39357, 39358 and 40070, respectively.

REFERENCES:
patent: 4719180 (1988-01-01), Eaton et al.
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Lawn et al., "The Isolation and Characterization of Linked Delta- and Beta-Globin Genes from a Cloned Library of Human DNA", Cell 15: 1157 ( 1978).
Myers et al., "Cloning a cDNA for the Pro-Alpha2 Chain of Hyman Type I Collagen", Proc. Natl. Acad. Sci., U.S.A. 78: 3516 (1981).
Houghton et al., "The Amino-Terminal Sequence of Human Fibroblast Interferon as Deduced from Reverse Transcripts Obtained Using Synthetic Oligonucleotide Primers", Nucleic Acids Res. 8: 1913 (1980).
Frey et al., "The Biosynthetic Precursor of Epidermal Growth Factor and the Mechanism of Its Processing", Proc. Natl. Acad. Sci. U.S.A. 76: 6294 (1979).
Scott et al.: Science 221, 236 (1983).
Britten et al.: Quarterly Rev. Biol. 46, 111 (1971).
Gray et al.: Nature 303, 722 (1983).
Bell et al., (1986), Nucleic Acids Research 14:21:8427-8446.

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