Hybrid cell lines that produce monoclonal antibodies to epiderma

Details Hybrid cell lines that produce monoclonal antibodies to epiderma Hybrid cell lines that produce monoclonal antibodies to epiderma

1987-03-09

1990-07-24

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435948, 530387, 424 858, C12N 500, C12R 191, C07K 1512, A61K 39395

Patent

active

049435337

ABSTRACT:
Hybrid cell lines that synthesize and secrete monoclonal antibodies against epidermal growth factor receptor generated by the fusion of myeloma cells to lymphocytes immunized with epidermal growth factor receptor are disclosed. The method of generating the hybridomas, as well as therapeutic and diagnostic uses of the monoclonal antibodies in both cancer treatment and research are also disclosed.

REFERENCES:
Cohen et al., "Epidermal Growth Factor-Receptor-Protein Kinase Interactions", J. Biol. Chem., vol. 255, no. 10; 1980; pp. 4834-4842.
Grimm et al., "Immunoprecipitation of the EGF Receptor Using Hybridoma Antibodies"; J. Supramol. Structure; vol. 9 (Suppl. 4), Abstract 437; 1980; p. 167.
Schreiber et al.; "Monoclonal Antibodies Against Receptor for Epidermal Growth Factor Induce Early and Delayed Effects of Epidermal"Growth Factor; PNAS, vol. 78, no. 12, Dec. 1981, pp. 7535-7539.
Sato et al., "Biological Effects in Vitro of Monoclonal Antibodies to Human Epidermal Growth Factor Receptors"; Mol. Biol. Med., vol. 1, no. 15; Aug. 1983; pp. 511-529.
Beheadian et al.; "Isolation of a Variant of A431 Cells Using a Ricin A-Conjugated Monoclonal Antibody Directed to EGF Receptors", J. Cell Biology, vol. 97 (5 Part 2), Abstract #1540, Aug., 1983; p. 408a.
Waterfield et al., "A Monoclonal Antibody to the Human Epidermal Growth Factor Receptor"; J. Cellular Biochem., vol. 20; 1982; pp. 149-161.
Schreiber et al., "Biological Role of Epidermal Growth Factor-Receptor Clustering"; J. Biol. Chem., vol. 258, no. 2, Jan. 25, 1983; pp. 846-853.
Grimm et al., "Hybridoma Antibodies to A431 Cell Plasma Membranes: Tests for Specific Immunoprecipitation of EGF Receptors", in Monoclonal Antibodies in Endocrine Research Raven Press, New York Eisenbarth (Ed.), 1981 pp. 99-110.
Gooi et al., "The Carbohydrate Specificities of the Monoclonal Antibodies 29.1, 455 and 3C1B12 to the Epidermal Growth Factor Receptor of A431 Cells." Bioscience Reports. 1985. vol. 5, pp. 83-94.
Masui et al. "Growth Inhibition of Human Tumor Cells in Athymic Mice by Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies." Cancer Research. Mar. 1984. vol. 44, pp. 1002-1007.
Kawamoto, Tomoyuki, et al., "Growth Stimulation of A431 Cells by Epidermal Growth Factor: Identification of High-Affinity Receptors for Epidermal Growth Factor By an Anti-Receptor Monoclonal Antibody." Proceedings of the National Academy of Sciences, U.S.A., Mar. 1983, 80:1337-1341.
Cohen, Stanley, et al., "Epidermal Growth Factor-Receptor-Protein Kinase Interactions." The Journal of Biological Chemistry. May 25, 1980; vol. 255, no. 10: 4834-4842.
Linsley, Peter S., and C. Fred Fox. "Direct Linkage of EGF to Its Receptor: Characterization and Biological Relevance." Journal of Supramolecular Structure. 1980, 14:441-459.

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