Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1982-02-02
1984-06-19
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Lymphokine
424 85, 260112R, 260112B, 435240, 4351722, 935 65, 935 99, 935103, 935108, A61K 3940, A61K 39395, C12N 500, C12N 1500
Patent
active
044552963
ABSTRACT:
Continuous hybrid cell lines for producing monoclonal antibodies directed against outer membrane antigens of Haemophilus influenzae type b have been developed. The hybrid cell lines were established by fusing differentiated lymphoid cells primed with outer membrane antigens of Haemophilus influenzae type b with hybridoma cells. The resulting fused cells were cloned and characterized as to antibody specificity against antigenic determinants of outer membranes of Haemophilus influenzae type b. One hybrid produces a monoclonal antibody which is capable of conferring passive immunity on Hib infected hosts.
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Glass, David, "Medicine's Micro Missiles", Science Digest, 30-31:114, (Jan. 1982).
Hansen, E. J., et al., "Detection of Anti-body Accessible Proteins on the Cell Surface of Haemophilus influenzae Type b," Infection and Immunity, vol. 33, No. 3, pp. 950-953, (Sep. 1981).
Hansen, E. J., et al., "Identification of Immunogenic Outer Membrane Proteins of Haemophilus influenzae Type b in the Infant Rat Model System," Infection and Immunity, vol. 32, No. 3, pp. 1084-1092.
Hansen, E. J., et al., "Isolation of Lymphocyte Hybridomas Producing Monoclonal Antibodies Specific for Haemophilus influenzae Type b Outer Membrane Antigens," Amer. Soc. Micro, B167; (Feb. 5, 1981).
Loeb, M. R., et al., "Outer Membrane Protein Composition in Disease Isolates of Haemophilus influenzae: Pathogenic and Epidemiological Implications," Infection and Immunity, vol. 30, No. 3, pp. 709-717 (Dec. 1980).
Hansen Eric J.
Kettman John R.
Robertson Stella M.
Board of Regents , The University of Texas System
Hazel Blondel
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