Hybrid cell line producing monoclonal antibody cytolytic to Tric

Details Hybrid cell line producing monoclonal antibody cytolytic to Tric Hybrid cell line producing monoclonal antibody cytolytic to Tric

1984-09-14

1987-11-17

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

4351722, 43524027, 435948, 436510, 436548, 530387, 530808, 530809, 935103, 935110, 935107, G01N 33571, C12N 1500, C12N 500, A61K 39395

Patent

active

047074426

ABSTRACT:
Hybridomas secreting monoclonal antibody having specificity for and cytolytic against Trichomonas vaginalis are provided. The cytolytic monoclonal antibodies specific for T. vaginalis are useful in detecting the presence of T. vaginalis among a general population of micro-organisms found in a biological sample. Detection of the T. vaginalis is evaluated by observing cell lysis of T. vaginalis after contacting the cultured micro-organisms with the cytolytic monoclonal antibody specific for T. vaginalis. Therapeutic uses of the monoclonal antibody as an immunological anti-microbial reagent for the treatment of T. vaginalis infection are also disclosed.

REFERENCES:
Torian et al, Inf. Immun., 43(1):270-275, Jan. 1984.
Fridenberg (ed.), Basic & Clinical Immunology, 2nd edition, Lange Medical Publications, Los Altos, Calif., (1978), 372,373,690.
Kohler et al, Nature, 256, 495-497 (1975).
"Identification of Immunogenic and Antibody-Binding Membrane Proteins of Pathogenic Trichomonas vaginalis", John F. Alderete, Infection and Immunity, vol. 40(1), pp. 284-291 (Apr. 1983).
"Antigen Analysis of Several Pathogenic Strains of Trichomonas vaginalis", John F. Alderete, Infection and Immunity, vol. 39(3), pp. 1041-1047 (Mar. 1983).
"Enzyme Linked Immunosorbent Assay for Detecting Antibody to Trichomonas vaginalis", John F. Alderete, British Journal of Venereal Diseases, vol. 60, pp. 164-170 (1984).

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