Hybrid cell line for producing monoclonal antibody to a human mo

Details Hybrid cell line for producing monoclonal antibody to a human mo Hybrid cell line for producing monoclonal antibody to a human mo

1985-08-08

1990-03-27

Tarcza, J. E.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

436548, 935104, C12N 0500, G01N 3354

Patent

active

049120450

ABSTRACT:
Hybrid cell line for production of monoclonal antibody to an antigen found on normal human monocytes and granulocytes. The hybrid is formed by fusing splenocytes from immunized BALB/cJ mice with P3X63Ag8Ul myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.

REFERENCES:
patent: 4364936 (1982-12-01), Kung et al.
Brown et al., "The Distribution of HLA on Human Lymphoid, Bone Marrow, and Peripheral Blood Cells", European Journal of Immunology 9, pp. 272-275 (1979).
Breard et al., "A Monoclonal Antibody Reactive with Human Peripheral Blood Monocytes", The Journal of Immunology 124(4), pp. 1943-1948 (1980).
Ugolini et al., "Initial Characterization of Monoclonal Antibodies Against Human Monocytes", Proceedings of the National Academy of Sciences 77(11), pp. 6764-6768 (1980).
Springer et al., "Mac-1: A Macrophage Differentiation Antigen Identified by Monoclonal Antibodies", European Journal of Immunology 9, pp. 301-306 (1979).
Reinherz et al., "Separation of Functional Subsets of Human T Cells by a Monoclonal Antibody", Proceedings of the National Academy of Sciences 76(8), pp. 4061-4065 (1979).
Reinherz et al., Journal of Experimental Medicine 151, pp. 969-974 (1980).

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