Hybrid cell line for producing monoclonal antibody to a human mo

Details Hybrid cell line for producing monoclonal antibody to a human mo Hybrid cell line for producing monoclonal antibody to a human mo

1989-08-03

1993-03-23

Sauders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

436548, 935110, G01N 33577

Patent

active

051963108

ABSTRACT:
Hybrid cell line for production of monoclonal antibody to an antigen found on normal human monocytes and granulocytes. The hybrid is formed by fusing splenocytes from immunized BALB/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.

REFERENCES:
patent: 4364936 (1982-12-01), Kung et al.
Reinherz et al., Journal of Experimental Medicine, 151, pp. 969-974 (1980).
Brown et al., European Journal of Immunology 9, pp. 272-275 (1979).
Breard et al., The Journal of Immunology 124(4), pp. 1943-1948 (1980).
Ugolini et al., Proceedings of the National Academy of Sciences 77(11) pp. 6764-6768 (1980).
Springer et al., European Journal of Immunology 9, pp. 301-306 (1979).
Hurrell, Monoclonal Hybridoma Antibodies: Techniques and Applications 1982, pp. 181-186.
Todd et al., The Journal of Immunology, vol. 126, No. 4, Apr. 1981, pp. 1435-1441.
Reinherz, E. L. et al., "Separation of Functional subsets of human T cells by a monoclonal antibody", Proc Natl Acad. Sci., vol. 76, No. 8, pp. 4061-4065, Aug. 1979.

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