Hybrid calcitonin

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Calcitonin; related peptides

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530317, 530324, 514 11, 930 60, A61K 14585

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058310002

ABSTRACT:
The improved hybrid calcitonin has a peptide segment in human calcitonin and a peptide segment in calcitonin derived from animals other than humans, such as eel, salmon and chicken. Each of the human or human analog calcitonins and the calcitonins derived from animals other than humans may be either native calcitonin or an analog thereof. The hybrid calcitonin has the outstanding advantage that it exhibits biological activities as strong as eel, salmon and chicken calcitonin while causing no side effects including nausea, disorders in the functions of the digestive tract or antigenicity.

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Rene Maier et al, "Analogs of human calcitonin, I. Influence of modifications in amino acid positions 29 and 31 on hypocalcaemic activity in the rat," FEBS Letters, vol. 48, No. 1, pp. 68-71, (1974).
R. Maier, "Analogues of Human Cacitonin," Calcitonin Tissue Research, vol. 21, Suppl., pp. 317-320, (1976).

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