Hybrid botulinal neurotoxins

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex

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4242391, 435220, 435842, 530350, 530402, 530412, 530825, 536 232, 536 237, 514 12, A61K 39385, A61K 3908, C12P 2106, C12N 952

Patent

active

059390700

ABSTRACT:
A hybrid botulinal neurotoxin is disclosed. In one embodiment, the neurotoxin comprises a combination of a botulinal neurotoxin heavy chain and light chain, wherein the light chain and heavy chain are not of the same serotype. A method for creating hybrid neurotoxins comprised of different functional domains is also disclosed.

REFERENCES:
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P. Moore, Handbook of Botulinum Toxin Treatment, Blackwell Science Inc., Osney Mean, Oxford, UK, 1995. Table of Contents Only.
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Schantz et al. Microb. Rev. (1992) 56:80-99. "Properties and Uses of Botulinum Toxin and Other Microbialneurotoxins in Medicine".
Waller et al Neurosci Lett (1991) 122:132-134 "Cooperative Action of the Light Chain of Tetanus Toxin and the Heavy Chain . . . ".
Peeters et al (1989) J. Immunol. Meth. 120:133-143 "Comparison of Four Bifunctional Reagents for Coupling Peptides to Proteins and the Effect . . . ".
Humbleton et al (1992) Brit Med J 304:959-960. "Antitoxins and Botulinum Toxin . . . ".
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