Hybrid antitumor compounds containing a cyclic enediyne and a DN

Details Hybrid antitumor compounds containing a cyclic enediyne and a DN Hybrid antitumor compounds containing a cyclic enediyne and a DN

1993-10-05

1995-03-07

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514422, 514383, 514397, 514407, 514343, 514340, 514341, 514290, 514314, 5482654, 5483111, 5483124, 5483137, 5483147, 5483641, 5483651, 548492, 548524, 546276, 546278, 546279, 546281, 546101, 546169, 546175, A61k 3140, A61k 3144, C07D20910, C07D20750, C07D40108, C07D23358

Patent

active

053958497

ABSTRACT:
The present invention provides novel antitumor agents which are hybrid molecules consisting of a cyclic enediyne unit attached to a DNA-binding unit via a linker unit, and having the general formula (I)

REFERENCES:
D. L. Boger and J. Zhou, "CDPI.sub.3 -Enediyne and CDP1.sub.3 -EDTA Conjugates: A New Class of DNA Cleaving Agents", Journal of Organic Chemistry, 58, pp. 3018-3024, 1993.
K. C. Nicolaou, et al, "Chemistry and Biology of Natural and Designed Enediynes", Proceedings of the National Academy of Sciences, USA, 90, pp. 5881-5888, 1993.
K. C. Nicolaou and W. M. Dai, "Chemistry and Biology of the Enediyne Anticancer Antibiotics", Angewandte Chemie, 30, No. 11, pp. 1387-1416, 1991.
Masahiko Tokuda, et al, "Synthesis of a Hybrid Molecule Containing Neocarzinostatin Chromophore Analogue and Minor Groove Binder", Tetrahedron Letters, 34, No. 4, pp. 669-672, 1993.
K. Toshima, et al, "Design, Synthesis and DNA Cleaving Profiles of Hybrids Containing the Novel Enediyne and Naturally Occurring DNA Intercalators", Journal of the Chemical Society, Chemical Communications, USA, pp. 1525-1527, 1993.

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