Hybrid alpha-glucoside transporter

Details Hybrid alpha-glucoside transporter Hybrid alpha-glucoside transporter

2008-09-09

2011-11-01

Li, Ruixiang (Department: 1646)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Fungi

C435S320100, C536S023100

Reexamination Certificate

active

08048667

ABSTRACT:
The present invention relates to alpha-glucoside transporters which can promote assimilation of maltose/maltotriose contained in wort, etc., and so on. Especially in relation to glucose-induced inactivation/degradation, the present invention relates to alpha-glucoside transporters which are less susceptible to glucose-induced inactivation/degradation and can take up maltotriose like AGT1, by constructing the hybrid of AGT1 and MAL21. By using, e.g., a yeast expressing the alpha-glucoside transporter of the present invention, the fermentation rate of moromi mash containing oligosaccharides such as maltose/maltotriose can be accelerated.

REFERENCES:
patent: 6-245750 (1994-09-01), None
Dietvorst et al. “Maltotriose Utilization in Lager Yeast Strains:MTTIEncodes a Maltotriose Transporter” (2005)Yeast22(10):775-788.
Medintz et al. “A PEST-like Sequence in the N-Terminal Cytoplasmic Domain ofSaccharomycesMaltose Permease is Required for Glucose-Induced Proteolysis and Rapid Inactivation of Transport Activity” (2000)Biochemistry39(15):4518-4526.
Gadura et al. “Sequences in the N-terminal Cytoplasmic Domain ofSaccharomyces cerevisiaeMaltose Permease are Required for Vacuolar Degradation but not Glucose-Induced Internalization” (2006)Curr. Genet. 50(2): 101-114 .
Kodama et al. “Improvement of Maltose Fermentation Efficiency: Constitutive Expression ofMALGenes in Brewing Yeasts” (1995)J. Am. Soc. Brew. Chem. (1995) 53(1):24-29.
Han et al. “Characterization of theAGT1Encoding a General α-Glucoside Transporter fromSaccharomyces” (1995)Molecular Microbiology17(6):1093-1107.
Brondijk et al. “Catabolite Inactivation of Wild-type and Mutant Maltose Transport Proteins inSaccharomyces cerevisiae” (1998).J. Biol. Chem. 273(25):15352-15357.
U.S. Appl. No. 12/442,143 to Hatanaka et al., entitled “Glucose-Induced Inactivation/Degradation-Resistant Transporter Gene and Use Thereof” which application is the National Stage of PCT/JP2008/066237, filed Sep. 9, 2008.
U.S. Appl. No. 12/442,121 to Hatanaka et al., entitled “Glucose-Induced Inactivation/Degradation-Resistant Transporter Gene and Use Thereof” which application is the National Stage of PCT/JP2008/066241, filed Sep. 9, 2008.

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