Hyaluronidase from the Hirudinaria manillensis isolation,...

Details Hyaluronidase from the Hirudinaria manillensis isolation,... Hyaluronidase from the Hirudinaria manillensis isolation,...

2006-05-23

2006-05-23

Patterson, Jr., Charles L. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S232000, C435S320100, C435S252300, C424S094620, C424S094500, C536S023200

Reexamination Certificate

active

07049124

ABSTRACT:
The present invention relates to the isolation, purification and characterization of a hyaluronidase which derives from the tropical leechHirudinaria manillensis. Therefore, according to this invention, the enzyme was called “manillase”. The invention is furthermore concerned with the recombinant method of production of manillase which includes the disclosure of DNA and amino acid sequences as well as of expression vectors and host systems. Finally, the invention relates to the use of manillase for therapeutic purposes, for example, for the treatment of myocardial diseases, thrombotic events and tumors.

REFERENCES:
patent: 5827721 (1998-10-01), Stern et al.
patent: 5976841 (1999-11-01), Wnendt et al.
patent: 0 193330 (1986-09-01), None
C.P. Jones and R.T. Sawyer: “Heparin Inhibits Mammalian, But Not Leech Hyaluronidase,” Thrombin Research, vol. 55, No. 6, 1989, pp. 791-796, XP000953413.

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