Hyaluronidase

Details Hyaluronidase Hyaluronidase

1986-02-14

1989-04-11

Rollins, John

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435201, 514912, 514913, A61K 3754

Patent

active

048205168

ABSTRACT:
The hyaluronidase, which is a hyaluronic acid-specific endo-.beta.-glucuronidase, having a molecular weight of about 28,500 in non-reduced form, is derived from buffalo leeches (that is, leeches of the sub-family Hirudinariinae, such as the species Hirudinaria manillensis or Poecilobdella granulosa).
The hyaluronidase, which cleaves hyaluronic acid, but not chondroitin, chondroitin -4- sulphate, chondroitin -6- sulphate or heparin, is considerably more stable at high temperatures and extremes of pH than known leech hyaluronidase. It has a wide range of uses where breakdown of hyaluronic acid is required; of particular interest is in pharmaceutical or veterinary formulations, either as an active agent or a spreading or percutaneous factor. The hyaluronidase is useful for stimulating flow of physiological fluids in the eye (for example, in the treatment of glaucoma).

REFERENCES:
patent: 4534967 (1985-08-01), Jacobson et al.
R. T. Sawyer, North American Freshwater Leeches (Urbana, IL: Univ. of Illinois Press), pp. 66-69, 72.
R. T. Sawyer, Leech Biology and Behaviour, vol. II, (Oxford: Clarendon Press, 1986), p. 496.
Linker et al., reported in Nature, 180:810-811 (1957).
Linker et al., "The Production of Hyaluronate Oligosaccharides . . . ", J. Biol. Chem., 235:924-927 (1960).
Budds et al., "A Comparison of the Properties of the Hyaluronidases . . . ", Comp. Biochem. Physiol. 87B:497-500 (1987).
H. Yuki et al., J. Biol. Chem. 248(5):1878-1879, 1963.

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