Hyaluronic acid-methotrexate conjugate

Details Hyaluronic acid-methotrexate conjugate Hyaluronic acid-methotrexate conjugate

2005-04-01

2010-10-05

Lukton, David (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S054000, C514S260100

Reexamination Certificate

active

07807675

ABSTRACT:
An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.

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