Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-06-08
2011-10-25
Cordero Garcia, Marcela M (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S002700, C530S324000
Reexamination Certificate
active
08044022
ABSTRACT:
Several species of bacteria capable of invasive infections, such asS. pyogenes, S. equiandP. multocida, contain hyaluronic acid (HA) in their capsules. Bacterial species such asStaphylococcus aureusand related Staphylococci have capsules that contain acidic polysaccharides. Bacterial capsule or bacterial surface binding peptides were synthesized and tested in a culture model of invasive bacterial infections, specifically translocation through polarized keratinocyte cultures. The peptides reduced the translocation of a variety of bacterial species, with a concomitant increase in bacterial internalization by the keratinocytes. In vivo, subcutaneous inoculation of encapsulated GAS treated with peptides delayed bacterial dissemination. In a mouse surgical wound model infected withS. aureus, treatment with peptides reduced the numbers of bacteria and inflammation at the wound site.
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Lee et al. Modulation of the Local Neutrophil Response by a Novel Hyaluronic Acid-Binding Peptide Reduces Bacterial Burden during Staphyloccal Wound Infection. Infection and Immunity, Oct. 2010. vol. 78, No. 10, pp. 4176-4186.
Charlton Bernard T.
Johnson Wendy
Kolodka Tadeusz
Ade & Company Inc.
Cordero Garcia Marcela M
Williams Michael R.
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