Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2006-08-08
2006-08-08
Wax, Robert A. (Department: 1653)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
C435S101000, C435S193000
Reexamination Certificate
active
07087413
ABSTRACT:
The present invention relates to a nucleic acid segment having a coding region segment encoding enzymatically activeStreptococcus equisimilishyaluronate synthase (seHAS), and to the use of this nucleic acid segment in the preparation of recombinant cells which produce hyaluronate synthase and its hyaluronic acid product. Hyaluronate is also known as hyaluronic acid or hyaluronan.
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“The Production of Capsules, Hyaluronic Acid and Hyaluronidase by Group A and Group C Streptococci”, MacLennan, J. Gen. Microbiol., 14:134-142 (1956).
“The Isolation and Characterization of a Hyaluronidase Produced by a Capsulated Strain of Group C Streptococcus”, MacLennan, J. Gen. Microbiol., 14:143-152 (1956).
“The Biosynthesis of Hyaluronic Acid by Group A Streptococcus”, Markovitz et al., J. Biol. Chem., 234 (9):2343-2350 (1959).
“Biosynthesis of Hyaluronic Acid by Streptococcus”, Sugahara et al., J. Biol. Chem., 254:6252-6261 (1979).
“Streptococcal Hyaluronic Acid: Proposed Mechanisms of Degradation and Loss of Synthesis During Stationary Phase”, Van de Rijn, J. Bacteriol., 156(3):1059-1065 (1983).
“Solubilization of Hyaluronic Acid Synthetic Activity from Streptococci and its Activation with Phospholipids”, Triscott et al., J. Biol. Chem., 261(13):6004-6009 (1986).
“Isolation of Streptococcal Hyaluronate Synthase”, Prehm et al., Biochem. J., 235:887-889 (1986).
“Homologs of the Xenopus Developmental Gene DG42 are Present in Zebrafish and Mouse and are Involved in the Synthesis of Nod-Like Chitin Oligosaccharides During Early Embryogenesis”, Semino et al., Proc. Natl. Acad. Sci. USA, 93:4548-4553 (1996).
“Enzymological Characterization of the Pasteurella Multocida Hyaluronic Acid Synthase”, DeAngelis, Biochemistry, 35 (30): 9768-9771 (1996).
“Molec
DeAngelis Paul
Kumari Kshama
Weigel Paul H.
Dunlap Codding & Rogers P.C.
The Board of Regents of the University of Oklahoma
Wax Robert A.
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