Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2006-10-03
2006-10-03
Wax, Robert A. (Department: 1653)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
Reexamination Certificate
active
07115405
ABSTRACT:
The present invention relates to a nucleic acid segment having a coding region segment encoding enzymatically active hyaluronate synthase (HAS), and to the use of this nucleic acid segment in the preparation of recombinant cells which produce hyaluronate synthase and its hyaluronic acid product. Hyaluronate is also known as hyaluronic acid or hyaluronan.
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“The Isolation and Characterization of a Hyaluronidase Produced by a Capsulated Strain of Group C Streptococcus”, MacLennan, J. Gen. Microbiol., 14:143-152 (1956).
“The Biosynthesis of Hyaluronic Acid by Group A Streptococcus”, Markovitz et al., J. Biol. Chem., 234 (9):2343-2350 (1959).
“Biosynthesis of Hyaluronic Acid by Streptococcus”, Sugahara et al., J. Biol. Chem., 254:625-6261 (1979).
“Streptococcal Hyaluronic Acid: Proposed Mechanisms of Degradation and Loss of Synthesis During Stationary Phase”, Van de Rijn, J. Bacteriol., 156(3):1059-1065 (1983).
“Solubilization of Hyaluronic Acid Synthetic Activity from Streptococci and its Activation with Phospholipids”, Triscott et al., J. Biol. Chem., 261(13):6004-6009 (1986).
“Isolation of Streptococcal Hyaluronate Synthase”, Prehm et al., Biochem. J., 235:887-889 (1986).
“Homologs of the Xenopus Developmental Gene DG42 are Present in Zebrafish and Mouse and are Involved in the Synthesis of Nod-Like Chitin Oligosaccharides During Early Embryogenesis”, Semino et al., Proc. Natl Acad. Sci. USA, 93:4548-4553 (1996).
“Enzymological Characterization of the Pasteurella Multocida Hyaluronic Acid Synthase”, DeAngelis, Biochemistry, 35 (30): 9768-9771 (1996).
“Molecular Cloning, Expr
DeAngelis Paul
Kumari Kshama
Weigel Paul H.
Dunlap Codding & Rogers P.C.
The Board of Regents of the University of Oklahoma
Wax Robert A.
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