Hyaluronan synthase gene and uses thereof

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07109011

ABSTRACT:
The present invention relates to a nucleic acid segment having a coding region segment encoding enzymatically activeStreptococcus equisimilishyaluronate synthase (seHAS), and to the use of this nucleic acid segment in the preparation of recombinant cells which produce hyaluronate synthase and its hyaluronic acid product. Hyaluronate is also known as hyaluronic acid or hyaluronan.

REFERENCES:
patent: 4224179 (1980-09-01), Schneider
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4511478 (1985-04-01), Nowinski et al.
patent: 4517295 (1985-05-01), Bracke et al.
patent: 4708861 (1987-11-01), Popescu et al.
patent: 4780414 (1988-10-01), Nimrod et al.
patent: 4782046 (1988-11-01), Brown et al.
patent: 4784990 (1988-11-01), Nimrod et al.
patent: 4801539 (1989-01-01), Akasaka et al.
patent: 5015577 (1991-05-01), Weigel et al.
patent: 5023175 (1991-06-01), Hosoya et al.
patent: 5071751 (1991-12-01), Morita et al.
patent: 5651982 (1997-07-01), Marx
patent: 5948900 (1999-09-01), Yother et al.
patent: RE37336 (2001-08-01), Weigel et al.
patent: 6423514 (2002-04-01), Briskin
patent: 6455304 (2002-09-01), Weigel et al.
patent: 6492150 (2002-12-01), McDonald
patent: 0036776 (1988-05-01), None
patent: 0195303 (1989-11-01), None
patent: 0144019 (1990-06-01), None
patent: 0266578 (1993-07-01), None
patent: 0244757 (1994-11-01), None
patent: 2249315 (1992-05-01), None
patent: 62032893 (1987-02-01), None
patent: 63094988 (1988-04-01), None
patent: 4-158796 (1992-06-01), None
patent: 91/03559 (1991-03-01), None
patent: 94/00463 (1994-01-01), None
patent: 95/24497 (1995-09-01), None
patent: 95/33067 (1995-12-01), None
patent: 97/20061 (1997-06-01), None
“The Biosynthesis of Hyaluronic Acid by Streptococcus,” Stoolmiller, et al., Journal of Biological Chemistry, vol. 244, No. 2, pp. 236-246 (1969).
“Modern Genetics,” Ayala, et al., Benjamin/Cummings Publishing Col., Menlo Park CA, p. 45 (1980).
“Strains ofEscherichia coliCarrying the Structural Gene for Histidyl-tRNA Synthetase on a High Copy-Number Plasmid,” Eisenbeis, et al., Mol. Gen. Genet. 183:115-122 (1981).
“Synthesis of Hyaluronate in Differentiated Teratocarcinoma Cells,” Prehm, et al., J. Biochem, vol. 211, pp. 191-198 (1983).
“Isolation, Structure and Expression of Mammalian Genes for Histidyl-tRNA Synthetase,” Tsui, et al., Nucleic Acids Research, vol. 15, No. 8, pp. 3349-3367, (1987).
“Shuttle Vectors Containing a Multiple Cloning Site and a Lacza Gena for Conjugal Transfer of DNA fromEscherichia colito Gram-Positive Bacteria,” Trieu-Cout, et al., Gene, vol. 102, pp. 99-104, (1991).
“Analysis of theStreptococcalHyaluronic Acid Synthase Complex Using the Photoaffinity Probe 5-Azido-UDP-Glucuronic Acid,” Van de Rijn, et al., J. Biol., Chem., vol. 267, No. 34, pp. 24302-24306, (1992).
“Molecular Characterization of a Locus Required for Hyaluronic Acid Capsule Production in Group AStreptococci,” Dougherty, et al., J. Exp. Med., vol. 175, pp. 1291-1299, (1992).
“Hyaluronan,” Laurent, et al., FASEB Journal, vol. 6, pp. 2397-2404, (1992).
“Isolation of aStreptococcus pyogenesGene Locus that Directs Hyaluronan Biosynthesis in Acapsular Mutants and in Heterologous Bacteria,” DeAngelis, et al., J. Biol. Chem., vol. 268, No. 20, pp. 14568-14571, (1993).
“Hyaluronate Synthase: Cloning and Sequencing of the Gene fromStreptococcusSP.,” Lansing, et al., J. Biochem., vol. 289, pp. 179-184, (1993).
“Molecular Characterization of HASB from an Operon Required for Hyaluronic Acid Synthesis in Group aStreptococci,” Dougherty, et al., J. Biol. Chem., vol. 268, No. 10, pp. 7118-7124, (1993).
“Molecular Cloning, Identification, and Sequence of the Hyaluronan Synthase Gene from Group AStreptococcus pyogenes,” DeAngelis, et al., J. Biol. Chem., vol. 268, No. 26, pp. 19181-19184, (1993).
“Molecular Characterization of HASA From an Operon Required for Hyaluronic Acid Synthesis in Group AStreptococci,” Dougherty, et al., J. Biol. Chem., vol. 269, No. 1, pp. 169-175, (1994).
“TheStreptococcus pyogenesHyaluronan Sytnhase: Sequence Comparison and Conservation Among Various Group A Strains,” DeAngelis, et al., Biochem. and Biophy. Res. Comm., vol. 199, No. 1, pp. 1-10, (1994).
“The Production of Capsules, Hyaluronic Acid and Hyaluronidase by Group A and Group CStreptococci”, MacLennan, J. Gen. Microbiol., 14:134-142 (1956).
“The Isolation and Characterization of a Hyaluronidase Produced by a Capsulated Strain of Group CStreptococcus”, MacLennan, J. Gen. Microbiol., 14:143-152 (1956).
“The Biosynthesis of Hyaluronic Acid by Group AStreptococcus”, Markovitz et al., J. Biol. Chem., 234 (9):2343-2350 (1959).
“Biosynthesis of Hyaluronic Acid byStreptococcus”, Sugahara et al., J. Biol. Chem., 254:6252-6261 (1979).
“StreptococcalHyaluronic Acid: Proposed Mechanisms of Degradation and Loss of Synthesis During Stationary Phase”, Van de Rijn, J. Bacteriol., 156(3):1059-1065 (1983).
“Solubilization of Hyaluronic Acid Synthetic Activity fromStreptococciand its Activation with Phospholipids”, Triscott et al., J. Biol. Chem., 261(13):6004-6009 (1986).
“Isolation ofStreptococcalHyaluronate Synthase”, Prehm et al., Biochem. J., 235:887-889 (1986).
“Homologs of the Xenopus Developmental Gene DG42 are Present in Zebrafish and Mouse and are Involved in the Synthesis of Nod-Like Chitin Oligosaccharides During Early Embryogenesis”, Semino et al., Proc. Natl Acad. Sci. USA, 93:4548-4553 (1996).
“Enzymological Characterization of thePasteurella multocidaHyaluronic Acid Synthase”, DeAngelis, Biochemistry, 35 (30): 9768-9771 (1996).
“Molecular Cloning, Expression, and Characterization of the Authentic Hyaluronan Synthase from Group CStreptococcus equisimilis”, Kumari and Weigel, J. Biol. Chem., 272(51): 32539-32546 (1997).
“Hyaluronan Synthases”, Weigel et al., J. Biol. Chem., 272 (22): 13997-14000 (1997).
“Identification and Molecular Cloning of a Unique Hyaluronan Synthase fromPasteurella multocida”, DeAngelis et al., J. Biol. Chem., 273(14): 8454-8458 (1998).
Heldermon et al.; Site-directed mutation of conserved cysteine residues does not inactivate theStreptococcus pyogeneshyaluronan synthase. Glycobiology 2001, vol. 11, No. 12, pp. 1017-1024, see entire document.
“The Combinations of Haemoglobin with Oxygen and with Carbon Monoxide.”, Hill, J. Biochem., 7:471-480 (1913).
“Die Kinetik Der Invertinwirkung”, Michaelis and Menton, Biochem. Z., 49: 333-338 (1913) (No trnaslation available).
“The Role of the Mucoid Polysaccharide (Hyaluronic Acid) in the Virulence of Group A HemolyticStreptococci”, Kass et al., J. Of Exp. Med., 79:319-330 (1944).
“Cleavage of Structural Proteins During the Assembly of the Head of Bacteriophage T4”, Laemmli, Nature, 227:680-685 (1970).
“The Isolation and Characterization of Hyaluronic Acid fromPasteurella multocida”, Cifonelli, et al., Carbohydrate Research, 14, 272-276, (1970).
“A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding”, Bradford, Analytical Biochemistry, 72:248-254 (1976).
“Synthesis and Assembly of the Membrane Proteins inE. Coli”, Ito et al., Cell, 11:551-559 (1977).
“Electrophoretic Transfer of Proteins from Polyacrylamide Gels to Nitrocellulose Sheets: Procedure and Some Applications”, Biochemistry, 76: 4350-4354 (1979).
“Hyaluronidase Production by Type B Pasteurella Multocida from Cases ofHemorrhagic septicemia”, Carter, et al., Journal of Clinical Microbiology, p. 94-96, (1980).
“Hyaluronate Capsule Prevents Attachment of Group AStreptococcito Mouse Peritoneal Macrophages”, Whitnack et al., Infection and Immunity, 31(3):985-991 (1981).
ȁ

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Hyaluronan synthase gene and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hyaluronan synthase gene and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hyaluronan synthase gene and uses thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3538249

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.