Hyaluronan receptor protein

Details Hyaluronan receptor protein Hyaluronan receptor protein

1995-06-07

2002-08-06

Kemmerer, Elizabeth (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S300000, C530S324000

Reexamination Certificate

active

06429291

ABSTRACT:

The present invention relates to a novel hyaluronan receptor protein involved in cell locomotion or motility and in cell proliferation and transformation and to DNA sequences encoding this protein. The protein is designated Receptor for Hyaluronic Acid Mediated Motility or RHAMM.
In the description which follows, references are made to certain literature citations which are listed at the end of the specification.
BACKGROUND OF THE INVENTION
Hyaluronan or hyaluronic acid (“HA”) is a large glycosaminoglycan that is ubiquitous in the extracellular matrix and whose synthesis has been linked to cell migration, growth and transformation (Turley 1984; Toole et al, 1984; Iozzo 1985; Boudreaux et al., 1991). This glycosaminoglycan interacts with cell surfaces via specific protein receptors that mediate many of its biological effects (Turley 1992). Three distinct hyaluronan receptors, CD44 (Dalchau et al., 1980; Aruffo et al., 1990; Stamankovic et al. 1991), RHAMM II (Hardwick et al., 1992; Yang et al., 1993), and HARLEC (Forsberg and Gustafson 1991; Rampyari et al., 1988) have been previously isolated and characterized. These receptors regulate cell locomotion and have been implicated in malignant transformation.


REFERENCES:
patent: WO 93/21312 (1993-10-01), None
Aruffo, A. et al. (1990) “CD44 Is the Principal Cell Surface Receptor for Hyaluronate.”Cell,61, pp. 1303-1313.
Boudreau, N. et al. (1991) “Fibronectin, Hyaluronan and a Hyaluronan Binding Protein Contribute to Increased Ductus Arteriosus Smooth Muscle Cell Migration.”Devel. Biol.,143, pp. 235-247.
Dalchau, R. et al. (1980) “Monoclonal Antibody To A Human Brain-Granulocyte-T Lymphocyte Antigen Probably Homologous To The W 3/13 Antigen Of The Rat.”Eur. J. Immunol.,10, pp. 745-749.
Forsberg, et al. (1991) “Characterization and Purification of the Hyaluronan-Receptor on Liver Endothelial Cells.”Biochimica et Biophysica Acta,1078, pp. 12-18.
Hardwick, C., Hoare, K., Owens, R., Hohn, H.P., Hook, M., Moore, D., Cripps, V., Austen, L., Nance D.M. and Turley, E.A. (1992) “Molecular Cloning of a Novel Hyaluronan Receptor That Mediates Tumor Cell Motility.”J. Cell Biol.,117, pp. 1343-1350.
Iozzo, R.V. (1985) “Biology of Disease.”Lab. Invest.,53, pp. 373-396.
Raja, P.H., McGary, C.T. and Weigel, P.H. (1988) “Affinity and Distribution of Surface and Intracellular Hyaluronic Acid Receptors in Isolated Rat Liver Endothelial Cells.”J. Biol. Chem.,263, pp. 16661-16668.
Stemenkovic, I., Aruffo, A., Amist, M. and Seed, B. (1991) “The Hematopoietic and Epithelial Forms of CD44 are Distinct Polypeptides with Different Adhesion Potentials for Hyaluronate-Bearing Cells.”EMBO J.,10, pp. 343-348.
Toole, B.P. et al. (1984) “Hyaluronate-Cell Interactions.”The Role of Extracellular Matrix in Development,pp. 43-66.
Turley, E.A. (1992) “Hyaluronan and Cell Locomotion.”Cancer Met. Rev.,11, pp. 21-30.
Turley, E.A. (1984) “Proteoglycans and Cell Adhesion: Their Putative Role during Tumorigenesis.”Cancer Met. Rev.,3, pp. 325-339.
Yang, B., Zhang, L. and Turley, E.A. (1993) “Identification of Two Hyaluronan-binding Domains in the Hyaluronan Receptor RHAMM.”J. Biol. Chem.,268, pp. 8617-8623.

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