Hyaluronan receptor expressed in human umbilical vein endothelia

Details Hyaluronan receptor expressed in human umbilical vein endothelia Hyaluronan receptor expressed in human umbilical vein endothelia

1996-08-20

1998-07-21

Ulm, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 691, 536 235, C07K 14705

Patent

active

057836698

ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode the hyaluronan receptor (hr) from human umbilical vein endothelial cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode hr, expression vectors for the production of purified HR, antibodies capable of binding specifically to HR, hybridization probes or oligonucleotides for detecting the upregulation of HR encoding nucleotide sequences, genetically engineered host cells for the expression of HR, diagnostic tests for activated, angiogenic, inflamed or metastatic cells and/or tissues based on HR-encoding nucleic acid molecules and antibodies capable of binding specifically to the receptor.

REFERENCES:
Akiyama et al., "Introduction: Adhesion molecules in cancer. Part I," Semin. Cancer Biol., 4:215-218 (1993).
Ghosh, "The role of hyaluronic acid in health and disease: interactions with cells, cartilage and components of synovial fluid," Clinical and Exp. Pheumatology 12, pp. 75-82 (1994).
Knudson et al., "Hyaluronan-binding proteins in development, tissue homeostasis, and disease," The FASEB Journal, 7:1233-1241 (1993).
Hardwick et al., "Molecular Cloning of a Novel Hyaluronan Receptor That Mediates Tumor Cell Motility," J. Cell Biol., 117:1343-1350 (1992).
Laurent et al., "Hyaluronan," The FASEB Journal, 6:2397-2404.

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