Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-10-18
1993-01-05
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514295, 546 63, 546 97, A61K 31435, C07D21122
Patent
active
051770822
ABSTRACT:
The invention relates to compounds of the formulas ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 independently are hydrogen or lower alkyl, and the dotted ( . . . ) line is an optional double bond, and their pharmaceutically acceptable acid addition salts. The compounds of formulas I, II and III possess marked anticholinesterase activity and are useful as analeptic agents and as agents for the treatment of senile dementia and myasthenia gravis.
REFERENCES:
patent: 4929731 (1990-05-01), Kozikowski et al.
Thompson, et al., New England J. of Medicine vol. 323(7), 1990, pp. 445-448.
New Drugs and Clin. Res. (China) Published Jul. 25, 1985, vol. 4. No. 4:235.
Acta Pharmacologica Sinica, 1986 Mar: 7(2) 110-113.
Can. J. Chem. vol. 64, 837-839 (1986).
Journal of the Taiwan Pharmaceutical Association vol. 36 No. 1.1-7 (1984).
Merck Index, Ninth Edition Item #8179 Selagine.
Canadian Journal of Chemistry, 1989 67 (10) 1538-1540.
Han Yan-yi
Liu Jia-sen
Tang Xi-can
Yu Chao-mei
Bond Robert T.
Gould George M.
Isgro William G.
Ward E. C.
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