Huperzine a analogs as acetylcholinesterase inhibitors

Details Huperzine a analogs as acetylcholinesterase inhibitors Huperzine a analogs as acetylcholinesterase inhibitors

1991-05-01

1992-04-14

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 15, 546 97, 546134, 546249, A61K 31435, C07D22122

Patent

active

051048809

ABSTRACT:
An acetylcholinesterase inhibitor is provided of the general formula (I): ##STR1## wherein R.sub.1 is H, (C.sub.1 -C.sub.8)alkyl or halo; R.sub.2 is H or (C.sub.1 -C.sub.8)alkyl; R.sub.3 and R.sub.4 are individually H, (C.sub.1 -C.sub.8)alkyl, NO.sub.2, hydroxy or halo; R.sub.5 and R.sub.6 are individually H, (C.sub.1 -C.sub.8)akyl, aryl or aralkyl; R.sub.7 is H, halo or (C.sub.1 -C.sub.8)alkyl, R.sub.8 is halo or (C.sub.1 -C.sub.8)alkyl; R.sub.9 is absent or is H; and the bonds represented by--are individually absent or, together with the adjacent bond, form the unit C.dbd.C, with the proviso that if both of the bonds represented by--are present, R.sub.3 and R.sub.4 cannot both be H unless R.sub.7 or R.sub.8 is halo; and the pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 4929731 (1990-05-01), Kozikowski
R. J. Wurtman, Scientific Amer., 62 (1988).
J. S. Liu et al., Can. J. Chem., 64, 837 (1986).
W. A. Ayer et al., Can. J. Chem., 67, 1077, 1538 (1989).
Y. E. Wang et al., Acta Pharmacol. Sinica, 7, 110 (1986).
G. P. Vincent et al., Neurosci. Abst., 13, 884 (1987).
X. C. Tang et al., J. Neurosci. Res., 24, 276 (1989).
Y. S. Cheng et al., New Drugs and Clinical Remedies, 5, 197 (1986).
Y. Xia et al., J. Amer. Chem. Soc., 111, 4116 (1989).
Y. Xia et al., Tett. Letters, 30, 3291 (1989).
A. P. Kozikowski, J. Heterocyclic Chem., 27, 97 (1990).
J. R. Atack et al., J. Pharmacol. and Exper. Ther., 249, 194 (1989).
Kozikowski et al., J.A.C.S. 111, 4116 (1989).
Kozikowski et al., J. Chem. Soc. Perkins Trans. I, 195 (1990).
S. Yamada et al., Tett. Letters, 2343 (1973).
A. Dornow et al., Chem. Ber. 99, 244 (1966).
K. Schreiber et al., Chem. Ber. 93, 1848 (1900).
Tang et al., CA 106-12878n (1987).
Liu et al., Chem Abst. 107-115821p (1987).
Chen et al., Chem Abst. 108-143270x (1988).

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