Huntington's Disease Treatment

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C435S007100

Reexamination Certificate

active

10843209

ABSTRACT:
A method of identifying a 5′AMP-activated protein kinase inhibitor for treating a neurodegenerative disease. Disclosed are a method and a packaged product for treating a neurodegenerative disease. Also disclosed is a method for treating a 5′AMP-activated protein kinase-related disease and a related packaged product.

REFERENCES:
patent: 4968697 (1990-11-01), Hutchison
patent: 5714460 (1998-02-01), Gluckman et al.
patent: 6124125 (2000-09-01), Kemp et al.
patent: 2004/0229837 (2004-11-01), Chern et al.
Gamble J, Lopaschuk GD. 1997. Insulin inhibition of 5′ adenosine . . . Metabolism 46(11):1270-1274.
Moore, F. et al. 1991. Evidence that AMP triggers . . . Eur J Biochem 199:691-697.
Bonelli, RM and Hofmann, P. 2004. A review of the treatment options for Huntington's disease. Exert Opin. Pharacother. 5(4):767-776.
Popoli, P, Pezzola, A, Reggio, R, Caporali, MG, and de Carolis, AS. 1994. CGS21680 anatagonizes motor activity . . . European Journal of Pharmacology 257:R5-R6.
Chern, Y. and Lee, Y-C. 2004. Application of CGS21680 and other agonists . . . http://www.sinica.edu.tw/˜ip/Technology—e/12—MedBio/12A-911101—e.htm. Last updated Apr. 26, 2004.
Hawley, SA et al. 5′-AMP activates the AMP-activated protein kinase cascade . . . 1995. J Biol Chem 45:27168-27191.
Davies, SP et al. 1990. Location and function of three sites . . . Eur J Biochem 187:183-190.
Chen, Z-P et al. 1999. AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS letters 443:285-289.
Jarvis et al. 1989. [3H]CGS21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rate brain. J Pharm Exp Therap 251(3):888-893.
Suh YH et al. 2002. Pharmacological Reviews 54:469-525.
Shaw RJ et al. 2004. PNAS 101:3329-3335.
Sigma Catalog 2000-2001. p. 229.
Sigma Catalog 1994. p. 582.
Gamble, J. et al. 1997. Metabolism 46:1270-1274.
Feigin et al. 2002. Curr Opin Neurol 15:483-489.
Senatorov et al. 2004. Mol Psychiatry 9:371-385.
Mazumder et al., 2003. Trends in Biochemical Sciences 28:91-98.
Hsiao-Chun Cheng et al. “Essential Role of cAMP-response Element-binding Protein Activation by A2AAdenosine Receptors in Rescuing the Nerve Growth Factor-induced Neurite Outgrowth Impaired by Blockage of the MAPK Cascade”. Journal of Biological Chemistry 277(37):33930-33942, 2002.
Wenzhen Duan et al. “Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice”, PNAS 100(5):2911-2916, Mar. 4, 2003.
Robert J. Ferrante et al. “Neuroprotective Effects of Creatine in a Transgenic Mouse Model of Huntington's Disease”. Journal of Neuroscience 20(12):4389-4397, Jun. 15, 2000.
Mari Garseth et al. “Proton Magnetic Resonance Spectorscopy of Cerebrospinal Fluid in Neurodegenerative Disease: Indication of Glial Energy Impairment in Huntington Chorea, but Not Parkinson Disease”. Journal of Neuroscience Research 60:779-782, 2000.
Nai-Kuei Huang et al. “Activation of Protein Kinase A and Atopical Protein Kinase C and A2ADeprivation in PC12 Cells”. Journal of Biological Chemistry 276(17):13838-13846, 2001.
Marc S. Hurlbert et al. “Mice Transgenic for an Expanded CAG Repeat in the Huntington's Disease Gene Develop Diabetes”. Diabetes 48:649-651, Mar. 1999.
Bruce G. Jenkins et al. “Nonlinear Decrease over Time in N-Acetyl Aspartate Levels in the Absence of Neuronal Loss and Increases in Glutamine and Glucose in Transgenic Huntington's Disease Mice”. Journal of Neurochemistry 74:2108-2119, 2000.
Guy A. Rutter et al. “Role of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostatis”. Journal of Biochemistry 375:1-16, 2003.
W. W. Winder. “Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle”. J. Appl. Physiol. 91:1017-1028, 2001.
Gabriela da Silva Xavier et al. “Role of AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression”. Journal of Biochemistry 371:761-774, 2003.

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