Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-11-09
2000-07-25
Caputa, Anthony C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
G01N 3353
Patent
active
060935499
ABSTRACT:
Proteins which specifically bind to huntingtin, the product of the Huntington's Disease locus (HD), are used in assays for screening drug candidates. These proteins, termed huntingtin associated proteins, bind to huntingtins of both normal and Huntington's Disease patients. However, the binding is stronger to the huntingtins from the patients. The strength of binding correlates with the number of glutamine repeats in the huntingtin, which itself correlates with the time of disease onset.
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Ross C. et al., The American Journal of Human Genetics, vol. 57, No. 4, Oct. 1995, p. 41, "Huntington's disease (HD): Involvement of the HD protein and identification of a cDNA coding for an associated protein (HAP-1)".
The Huntington's Disease Collaborative Research Group Cell, vol. 72, No. 6, Mar. 26, 1993, pp. 971-983, "A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes".
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Lanahan Anthony
Li Shi-Hua
Li Xiao-Jiang
Ross Christopher A.
Sharp Alan H.
Caputa Anthony C.
Hayes Robert C.
The Johns Hopkins University
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