Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1991-02-25
1992-05-19
Lee, Lester L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 72, 435 723, 435 71, 514 12, 530324, 930DIG820, 930DIG821, G01N 33567, C07K 710, A61K 3702
Patent
active
051148439
ABSTRACT:
The present invention relates to the use of peptide analogues as inhibitors of their respective naturally occurring peptides. The structure of the peptide analogues is exemplified by an internal region of the N-terminus of humoral hypercalcemic factor hHCF, and truncations thereof: hHCF(14-34)NH.sub.2, hHCF(13-34)NH.sub.2, hHCF(12-34)NH.sub.2, hHCF(11-23)NH.sub.2, hHCF(10-34)NH.sub.2, hHCF(9-34)NH.sub.2, hHCF(8-34)NH.sub.2 and various amino acid substitutions.
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Caulfield Michael P.
McKee Roberta L.
Nutt Ruth F.
Rosenblatt Michael
Caruso Charles M.
Lee Lester L.
Merck & Co. , Inc.
Mitri Salvatore C.
Wessendorf T. D.
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