Humanized monoclonal antibodies against human interleukin-4

Details Humanized monoclonal antibodies against human interleukin-4 Humanized monoclonal antibodies against human interleukin-4

1994-03-10

1997-01-28

Eisenschenk, Frank C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 701, 435 703, 435 711, 4352523, 4353201, 435 691, 435327, 435335, 435365, 5303873, 530324, 536 234, 536 235, 536 2353, 935 11, 935 15, 935 23, 935 71, 935 70, C07H 2104, C07K 1646, C12N 120, C12N 1500

Patent

active

055977103

ABSTRACT:
Humanized monoclonal antibodies are provided which are specific for human IL-4 and have properties unexpectedly superior to other, previously available humanized antibodies. Also provided are nucleic acids which encode the heavy and light chain variable regions of such monoclonal antibodies or antigenic fragments thereof; anti-idiotypic antibodies; and methods for detecting, measuring and immunopurifying human IL-4, and for blocking or mimicking the biological activity of human IL-4.

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