Humanized immunoglobulin reactive with α4β7...

Details Humanized immunoglobulin reactive with α4β7... Humanized immunoglobulin reactive with α4β7...

2008-07-22

2008-07-22

Schwadron, Ron (Department: 1644)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C536S023530, C435S325000, C435S328000, C435S320100

Reexamination Certificate

active

11511164

ABSTRACT:
The present invention relates to isolated nucleic acids encoding humanized immunoglobulins having binding specificity for α4β7 integrin, isolated nucleic acids encoding a humanized immunoglobulin heavy chain and isolated nucleic acids encoding a humanized light chain having binding specificity for α4β7 integrin. The invention also relates to expression vectors and host cells comprising a nucleotide sequence which encodes a humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7. The invention further relates to methods of preparing a humanized immunoglobulin, humanized immunoglobulin heavy chain and humanized immunoglobulin light chain that has binding specificity for α4β7 integrin.

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Hynes, R

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