Humanized antibodies to gamma-interferon

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C530S387100, C530S387300

Reexamination Certificate

active

09992524

ABSTRACT:
The invention provides humanized immunoglobulins that bind to and neutralize γ-interferon. The antibodies are useful for treatment of diseases of the immune system, particularly autoimmune diseases.

REFERENCES:
patent: 5530101 (1996-06-01), Queen et al.
patent: 5585089 (1996-12-01), Queen et al.
patent: 5693761 (1997-12-01), Queen et al.
patent: 5693762 (1997-12-01), Queen et al.
patent: 6329511 (2001-12-01), Vasquez et al.
Chen, C., et al. J. Exp. Med. Sep. 1992; 176:855-866.
Colman, P.M., “Effects of amino acid sequence changes on antibody-antigen interactions,”Res. Immunology, 145:33-36 (1994).

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