Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Reexamination Certificate
1999-05-19
2010-12-07
Swartz, Rodney P. (Department: 1645)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
C424S150100, C424S236100, C424S241100, C435S070210, C435S071300, C435S328000, C435S388000, C435S388000
Reexamination Certificate
active
07846435
ABSTRACT:
The invention provides humanized antibodies that specifically bind to, and preferably, neutralize, verotoxin II (VT2). The antibodies are useful for treating patients suffering from, or at risk of suffering, toxic effects of verotoxin.
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Perera et al., “Isolation and Characterization of Monoclonal Antibodies to Shiga-Like Toxin II of EnterohemorrhagicEscherichia coliand Use of the Monoclonal Antibodies in a Colony Enzyme-Linked Immunosorbent Assay,”J. Clinical Microbiology, 26(10):2127-2131 (1988).
Schmitt et al.., “Two Copies of Shiga-Like Toxin II-Related Genes Common in EnterohemorrhagicEscherichia coliStrains Are Responsible for the Antigenic Heterogeneity of the O157:H-Strain E32511,”Infection and Immunity, 59(3):1065-1073 (1991).
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Co Man Sung
Imaizumi Atsuchi
Kimura Tsuyoshi
Matsumoto Yoh-Ichi
Takeda Tae
PDL Biopharma, Inc.
Swartz Rodney P.
Teijin Limited
Townsend and Townsend / and Crew LLP
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