Humanized antibodies that recognize difucosyl Lewis blood group

Details Humanized antibodies that recognize difucosyl Lewis blood group Humanized antibodies that recognize difucosyl Lewis blood group

1993-04-22

1996-10-08

Hutzell, Paula K.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

5303873, 5303875, 53038885, 4241371, 4241551, A61K 39395, C07K 1628

Patent

active

055629032

ABSTRACT:
Humanized monoclonal antibodies that recognize the difucosyl Lewis blood group antigens Y-6 and B-7-2 are disclosed. The antibodies have a humanized light chain variable region and a humanized heavy chain variable region with CDRs from antibody BR55-2. Fragments of the antibodies and pharmaceutical compositions containing them are also disclosed.

REFERENCES:
Kabat, "Sequences of Proteins of Immunological Interest," 1987, USDHHS, pp. 50, 167.
Fahey et al. Clin Exp. Immunol. 88: 1-5, 1992.
Waldman,. Science 252:1657-1662, 1991.
Wawrzynczak et al. Clin, Exp. Immunol. 82:189-193, 1990.
Kimmel et al., J. Neurosurg. 66:161-171, 1987.
Schlom, in "Molecular Foundations of Oncology," S. Broder, Ed., Williams & Wilkins, 1991, pp. 95-134.
Riechmann et al, Nature, vol. 33224, pp. 323-327 (1988).
Queen et al, Pro. Nat. Acad. Sci. USA, vol. 86, pp. 10029-10033 (Dec. 1989) .

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