Humanized antibodies

Details Humanized antibodies Humanized antibodies

2007-07-17

2007-07-17

Huff, Sheela J. (Department: 1643)

Chemistry: molecular biology and microbiology

Vector, per se

C536S023100, C536S023530, C435S071100, C530S387300, C530S387100, C530S388220, C424S133100, C424S143100

Reexamination Certificate

active

10704071

ABSTRACT:
CDR-grafted antibody heavy and light chains comprise acceptor framework and donor antigen binding regions, the heavy chains comprising donor residues at at least one of positions (6, 23) and/or (24, 48) and/or (49, 71) and/or (73, 75) and/or (76) and/or (78) and (88) and/or (91). The CDR-grafted light chains comprise donor residues at at least one of positions (1) and/or (3) and (46) and/or (47) or at at least one of positons (46, 48, 58) and (71). The CDR-grafted antibodies are preferably humanized antibodies, having non human, e.g. rodent, donor and human acceptor frameworks, and may be used for in vivo therapy and diagnosis. A generally applicable protocol is disclosed for obtaining CDR-grafted antibodies.

REFERENCES:
patent: 4348376 (1982-09-01), Goldenberg
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 5530101 (1996-06-01), Queen et al.
patent: 5585089 (1996-12-01), Queen et al.
patent: 5618920 (1997-04-01), Robinson et al.
patent: 5693761 (1997-12-01), Queen et al.
patent: 5693762 (1997-12-01), Queen et al.
patent: 6180370 (2001-01-01), Queen et al.
patent: 0 239 400 (1987-09-01), None
patent: 0 323 806 (1989-07-01), None
patent: 0 328 404 (1989-08-01), None
patent: 0 365 209 (1990-04-01), None
patent: 0 403 156 (1990-12-01), None
patent: 0 451 216 (1991-10-01), None
patent: 0 682 040 (1995-11-01), None
patent: WO 89/07452 (1989-08-01), None
patent: WO 90/07861 (1990-07-01), None
patent: WO 92/04381 (1992-03-01), None
patent: WO 92/11018 (1992-07-01), None
patent: WO 92/15683 (1992-09-01), None
patent: WO 92/16553 (1992-10-01), None
Chothia, Cyrus and Lesk, Arthur M., “Canonical Structures for the Hypervariable Regions of Immunoglobulins”J. Mol. Biol., 196:901-917, (1987) (pp. 901 and 904).
Chothia, Cyrus, et al., “Conformations of Immunoglobulin hypervariable regions,”Nature, 342:877-883, (1989).
Jones, Peter T., et al., “Replacing the complementarity-determining regions in a human antibody with those from a mouse,”Nature, 321:522-525, (1986).
Queen, Cary, et al., “A humanized antibody that binds to the interleukin 2 receptor,”Proc. Natl. Acad. Sci. USA, 86:10029-10033, (1989).
Riechmann, Lutz, et al., “Reshaping human antibodies for therapy,”Nature, 332:323-327, (1988).
Roberts, S., et al., “Generation of an antibody with enhanced affinity and specificity for its antigen by protein engineering,”Nature, 328:731-734, (1987).
Verhoeyen, Martine, et al., “Reshaping Human Antibodies: Grafting an Antilysozyme Activity,”Science, 239:1534-1536 (1988).
Ward, Sally E., et al., “Binding activities of a repertoire of single immunoglobulin variable domains secreted fromEscherichia coli,” Nature, 341:544-546, (1989).
Chambers 20thCentury Dictionary (1973 Edition), p. 1128.

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