Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2004-01-21
2009-06-02
Gambel, Phillip (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C530S387100, C530S387300, C530S388150, C530S388200, C530S388230, C424S130100, C424S133100, C424S137100
Reexamination Certificate
active
07541033
ABSTRACT:
The present invention encompasses isolated antibodies, or antigen-binding portions thereof, that specifically bind mature human IL-1 Beta. These antibodies, or antigen-binding portions thereof, generally exhibit high binding affinities (low kooff values), reduced deamidation compared to the native antibody, and can be used to treat various diseases such as rheumatoid arthritis, osteoarthritis, or neuroinflammation.
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Jackson, Jeffrey R., et al. In Vitro Antibody Maturation—Improvement of a High Affinity, Neutralizing Antibody Against IL-1β. The Journal of Immunology, 1995, vol. 154, pp. 3310-3319.
Dickinson Craig Duane
Lu Jirong
Vasserot Alain Philippe
Watkins Jeffry Dean
Apelgren Lynn D.
Applied Molecular Evolution, Inc.
Gambel Phillip
Wen Sharon
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