Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1996-02-23
1999-02-23
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241301, 4241331, 4241411, 4241431, 4241441, 4241531, 4241731, 5303873, 53038822, 5303887, 53038873, A61K 39395, C07K 1628
Patent
active
058740821
ABSTRACT:
Methods for preventing or treating an antibody-mediated disease in patient are presented, the methods comprising administration of a humanized monoclonal antibody or fragment thereof that is capable of binding to a human CD40 antigen located on the surface of a human B cell, wherein the binding of the antibody to the CD40 antigen prevents the growth or differentiation of the B cell. Humanized monoclonal antibodies and fragments useful in these methods are also presented.
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Blackburn Robert P.
Chan Christina Y.
Chiron Corporation
Gambel Phillip
Pochopien Donald J.
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