Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-11-17
1999-04-06
Scheiner, Toni R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
53038822, 4241331, 4241431, C07K 1628, A61K 39395
Patent
active
058919961
ABSTRACT:
New humanized and chimeric monoclonal antibodies that recognize EGF-R and comprise an artificial sequence at least of the FRs of the heavy chain variable region of a human immunoglobulin. The hypervariable regions of both monoclonal antibodies is the following amino acid sequence: light chain:
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patent: 5470571 (1995-11-01), Herlyn
patent: 5530101 (1996-06-01), Queen
Article entitled: Cloning immunoglobulin variable domains for expression by the polymerase chain reaction. Authors: Rosaria Orlandi, Detlef H. Gussow, Peter T. Jones and Greg Winter. Published in the Proc. Natl. Acad. Sci. USA vol. 86, pp. 3833-3837, May 1989.
Catherine A. Kettleborough et al., "Isolation of tumor cell-specific single-chain Fv from immunized mice using phage-antibody libraries and the re-construction of whole antibodies from these antibody fragments", Eur. J. Immunol., vol. 24, 1994, pp. 952-955.
Mayumi Naramura et al., "Therapeutic potential of chimeric and murine anti-(epidermal growth factor receptor) antibodies in a metastasis model for human melanoma", Cancer Immunology Immunotherapy, vol 37, 1993, pp. 343-349.
Catherine A. Kettleborough et al., "Humanization of a mouse monoclonal antibody by CDR-grafting: the importance of framework residues on loop conformation", Protein Engineering, vol. 4, No. 7, 1991, pp. 773-783.
A. Fernandez et al., "A New Monoclonal Antibody for Detection of EGF-Receptors in Western Blots and Paraffin-Embedded Tissue Sections", Journal of Biochemistry, vol. 49, 1992, pp. 157-165.
Paul Carter et al., "Humanization of an anti-p185.sup.HER2 antibody for human cancer therapy", Proc. Natl. Acad. Sci. USA, vol. 89, May 1992, pp. 4285-4289.
Frias Ernesto Moreno
Mateo de Acosta del Rio Cristina Maria
Rodriguez Rolando Perez
Centro de Inmunologia Molecular
Johnson Nancy A.
Scheiner Toni R.
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