Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Anti-idiotypic
Reexamination Certificate
2007-07-25
2008-08-19
Blanchard, David J. (Department: 1643)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Anti-idiotypic
C424S130100, C424S133100, C424S138100, C424S155100, C530S387100, C530S387200, C530S387300, C530S387700
Reexamination Certificate
active
07413736
ABSTRACT:
A humanized form of an anti-idiotype antibody to CEA, e.g., hWI2, has conserved immunoreactivity. The clinical benefits of anti-CEA antibodies are maximized by using the humanized anti-idiotype as a clearing agent for anti-CEA antibodies or antibody fragments. The humanized anti-idiotype also can be used as an immunogenic vaccine.
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Bodey et al. Anticancer Research. 20:2665-2676; 2000.
Cerio et al. Oncogene, 2007. 26: 3594-3602.
Schreiber. Springer Semin Immunopathol, 1993. 15:235-246.
Hansen Hans
Leung Shui-on
Losman Michele J.
Blanchard David J.
Immunomedics Inc.
Nakashima Richard A.
Tungaturthi Parithosh K.
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