Humanin-like peptide and use thereof

Details Humanin-like peptide and use thereof Humanin-like peptide and use thereof

2006-05-30

2006-05-30

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S325000

Reexamination Certificate

active

07053053

ABSTRACT:
A novel polypeptide having a cell death inhibitory activity and use thereof is provided. The polypeptide and the polynucleotide encoding it can be used as a diagnostic, therapeutic or prophylactic agent for various diseases and disorders. Certain suitable diseases and disorders which may be diagnosed, treated, or prevented with the polypeptide and the polynucleotide encoding it are selected from neurodegenerative diseases, brain dysfunctions, cancers, immunological disease, infections, gastrointestinal diseases, circulatory diseases, and endocrine diseases. The polypeptide and the polynucleotide encoding it can be used as a cell death inhibitor.

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patent: WO 01/21787 (2001-03-01), None
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Hashimoto et al., “A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ,”PNAS98:6336-6341 (2001).
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Kimberley, “Human DNA sequence from clone RP11-396K16 on chromosome 6 contains ESTs, STSs and GSSs. Contains a mitochondrial 16s rRNA (MTRNR2) pseudogene,” Database Accession No. AL356135 XP-002280311. (Last updated Mar. 22, 2001).
Hashimoto et al., “Mechanisms of Neuroprotection by a Novel Rescue Factor Humanin from Swedish Mutant Amyloid Precursor Protein,”Biochemical and Biophysical Research Communications283:460-468 (2001).

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