Human zona pellucida protein 3 and uses thereof

Details Human zona pellucida protein 3 and uses thereof Human zona pellucida protein 3 and uses thereof

2006-05-02

2006-05-02

Le, Long V. (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007210, C435S007920, C436S501000

Reexamination Certificate

active

07037663

ABSTRACT:
The present invention provides a method to determine sperm activity comprising the steps of: (a) contacting an appropriate concentration of human zona pellucida protein 3 with an appropriate amount of sperm under conditions permitting the formation of a complex between the human zona pellucida protein 3 and the sperm; and (b) determining the complex formed. The invention further provides a method to determine sperm activity comprising the steps of (a) contacting an appropriate concentration of human zona pellucida protein 3 with an appropriate amount of sperm under conditions permitting an acrosome reaction to occur; and (b) determining the extent of the acrosome reaction. Finally, this invention provides a diagnosis kit for sperm activity comprising three (3) compartments with (a) an appropriate amount of human zona pellucida protein 3; (b) the reagents used for establishing the conditions for allowing the binding of sperm; and (c) the reagents used for establishing the conditions for allowing an acrosome reaction.

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Bleil, Jeffrey D. and Paul M. Wassarman. Jul. 19

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