Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Reexamination Certificate
2006-08-08
2006-08-08
Benzion, Gary (Department: 1637)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
C536S023100
Reexamination Certificate
active
07087430
ABSTRACT:
This invention relates to DNA libraries, in particular a human VNO cDNA library is described. Pheromone receptor cDNA once isolated is transfected into competent cells. The transfected cell lines provide a scaleable source of homogeneous material to develop efficient, automated high throughput screening assays for new vomeropherins, and thereby reduce the ongoing need for human volunteers in the preclinical phases of drug discovery. Identification and characterization of the human VNO receptor(s) will facilitate the development and commercialization of vomeropherins with improved specificity, and enhanced therapeutic efficacy in the treatment of the target diseases.
REFERENCES:
patent: 5858731 (1999-01-01), Sorge et al.
patent: 5891636 (1999-04-01), Van Gelder
patent: 5994623 (1999-11-01), Broglie et al.
patent: WO 97/14790 (1997-04-01), None
patent: WO 99/00422 (1999-01-01), None
patent: WO 9900422 (1999-01-01), None
patent: WO 01/25431 (2001-04-01), None
Axel, “The Molecular Logic of Smell”, Scientific American, Oct. 1995, pp. 154-159.
Barinaga, “Salmon Follow Watery Odors Home”, Science, Oct. 22, 1999, vol. 286, pp. 705-706.
Berliner, D. L. 1996. J. Steroid Biochem Molec Biol 58:1-2.
Berliner, D. L., L. Monti-Bloch, C. Jennings-White and V. Diaz-Sanchez 1996. J Steroid Biochem, Molec Biol 58:259-265.
Broadwell, R. D. 1975. J Comp Neurol 163:329-346.
Cao, Y., B. C. Oh, and L. Stryer. 1998. Proc Natl Acad Sci USA 95:11987-11992.
Dulac, et al, “A novel family of genes encoding putative pheromone receptors in mammals”, Cell, Oct. 20, 1995, 83; (2); pp. 195-206, XP002156990, United States.
Gaafar, H, A, A. A. Tantawy, A. A. Melis, D. M. Hennawy and H. M. Shehata, 1998, Acta Otolargyngol 118:408-412.
Gruber, et al., “Construction of SuperScript Human cDNA Libraries”, Focus 17 No. 2, pp. 43-44.
Herrada, et al., “A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution”, Cell, Aug. 22, 1997, 90; (4); pp. 763-773, XP002913897, United States.
Jacob, “Human Pheromones”, The Physiology of Taste, http://www.cf.ac.uk/uwcc/momed/jacob/teaching/sensory/pherom.html.
Kallmann, F., W. A. Schoenfeld and S. E. Barrera. 1943. Am J Ment Defic 48:203-236.
Kel, A., A. Ptitsyn V. Babenko, S. Meier-Ewert, and H. Lebrach. 1998. Bioinformatics 14:259-270.
Keverne, et al, “The vomeronasal organ”, Science, American Association For The Advancement of Science, U.S., vol. 286, No. 5440, Oct. 22, 1999, pp. 716-720, XP002157783, ISSN: 0036-8075.
Kevetter et al, “Connection of the Corticomedial Amygdala in the Golden Hamster. I. Efferents of the Vomeronasal Amygdala”, J of Comparative Neurology 197:81-89 (1991).
Krieger, et al., “Olfactory Reception in Invertebrates”, Science, Oct. 22, 1999, vol. 286, pp. 720-723.
Krieger, J., A. Schmitt, D. Löbel, T. Gudermann, G. Schultz, H. Breer, and I. Boekhoff. 1999. J Biol Chem 274:4656-4662.
Laurent, “A Systems Perspective On Early Olfactory Coding”, Science, Oct. 22, 1999, vol. 286, pp. 723-728.
Luscher, M. and P. Karlson. 1959. Nature 18:55-56.
Malakoff, “Following The Scent of Avian Olfaction”, Science, Oct. 22, 1999, vol. 286, pp. 704-705.
Matsunami, H. and L. B. Buck, 1997, Cell 90:775-784.
Meredith, M., 1983, in Pheromones and reproduction in mammals (Vandenbergh, ed.) pp. 199-252, Academic Press.
Mombaerts, “Seven-Transmembrane Proteins as Odorant and Chemosensory Receptors”, Science, Oct. 22, 1999, vol. 286, pp. 707-711.
Monti-Bloch, L. 1997. Chemical Senses 22:752.
Monti-Bloch, L. and B. I. Grosser. 1991. J. Steroid Biochem. Molec. Biol. 39:573-582.
Monti-Bloch, L. V. Diaz-Sanchez, C. Jennings-White and D. L. Berliner. 1998a. J. Steroid Biochem. Molec. Biol. 65:237-242.
Monti-Bloch, L, C. Jennings-White and D. L. Berliner. 1998b. Ann. N.Y. Acad. Sci. 855:373-389.
Monti-Bloch, L., C. Jennings-White, D. S. Dolberg and D. L. Berliner, 1994, Pyschoneuroendocrinology 19:673-686.
Moran, D. T., B. W. Jafek and J. C. Rowley III. 1991, J Steroid Biochem Molec Biol 39:545-552.
Mori, et al., “The Olfactory Bulb: Coding and Processing Of Odor Molecule Information”, Science, Oct. 22, 1999, vol. 286, pp. 711-715.
Quinton, Gonadotropin-Releasing Hormone Immunoreactivity in the Nasal Epithelia of Adults with Kallmann's Syndrome and Isolated Hypogonadotropic Hypogonadism and in the Early Midtrimester Human Fetus, The Journal of Clinical Endocrinology & Metabolism, Jan. 1997, vol. 82, No. 1, pp. 309-314, ISSN: 0021-972X.
Rodriguez, et al., “A putative pheromone receptor gene expressed in human olfactory mucosa”, Nature Genetics, Nature America, New York, U.S., vol. 26, Sep. 2000, pp. 18-19, XP002157781, ISSN: 1061-4036.
Ryba, N. J. P. and R. Tirindelli. 1997. Neuron 19:371-379.
Saito, H., M. L. Mimmack, E. B. Keverne, J. Kishimoto and P. C. Emson. 1998. Brain Res Molec Brain Res 60:215-227.
Schaeren-Wiemers, N. and A. Gerfin-Moser. 1993. Histochemistry 100:431-440.
Simon, M. I., M. P. Strathmann, and N. Gautam, 1991, Science 252:802-808.
Simms, et al., “TRIzol: A New Reagent for Optimal Single-Step Isolation of RNA”, Focus 15, No. 4, pp. 99-102.
Smith, T. D., M. I. Siegel, A. M. Burrows, M. P. Mooney, A. R. Burdi, P. A. Fabrizio and F. R. Clemente, 1998, Micro Res Tech 41:483-491.
Sobel, N., V. Prabhakaran, C. A. Hartley, J. E. Desmond, G. H. Glover, E. V. Sullivan and J. D. E. Gabrieli. 1999, Brain 122:209-217.
Stern et al., “Making Sense of Scents”, Science vol. 286, Oct. 22, 1999, pp. 703.
Stern, K. and M. K. McClintock. 1998, Nature 392:177-179.
Takami, S., M. L. Getchell, Y. Chen, L. Monti-Bloch, D. L. Berliner, L. J. Stenaas, and T. V. Getchell. 1993, Neuroreport 4:375-378.
Velasco, G., et al, “Nose Surgery and the Vomeronasal Organ”, Aesthetic Plastic Surgery 19:451-454, 1995.
Wysocki, C. J. 1979. Neurosci Biobehav Rev 3:301-341.
Wysocki, C. J. and J. J. Lepri. 1991. J. Steroid Biochem Molec Biol 39:661-669.
Berliner David L.
Herman Ronald C.
Babic Christopher M
Benzion Gary
Fox James A.
Heller Ehrman LLP
Pherin Pharmaceuticals, Inc.
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