Human virus causing respiratory tract infection and uses...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C435S320100, C530S333000, C530S333000

Reexamination Certificate

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07553944

ABSTRACT:
The present invention provides the complete genomic sequence of a novel human coronavirus, coined as coronavirus-HKU1 (“CoV-HKU1”), isolated in Hong Kong from a patient who had a recent history of visit to Schenzhen, China. The virus belongs to the order Nidovirales of the family Coronaviridae, being a single-stranded RNA virus of positive polarity. The invention also provides the deduced amino acid sequences of the complete genome of the CoV-HKU1. The nucleotide sequences and deduced amino acid sequences of the CoV-HKU1 are useful in preventing, diagnosing and/or treating the infection by CoV-HKU1. Furthermore, the invention provides immunogenic and vaccine preparations using recombinant and chimeric forms as well as subunits of the CoV-HKU1 based on the nucleotide sequences and deduced amino acid sequences of the CoV-HKU1.

REFERENCES:
patent: 2005/0266397 (2005-12-01), Ecker et al.
Yount B. et al. “Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59”, J Virol. Nov. 2002;76(21):11065-78.
Entraz Accession No. NC—001846.
Woo PC et al. “Phylogenetic and recombination analysis of coronavirus HKU1, a novel coronavirus from patients with pneumonia”. Arch Virol. Nov. 2005;150(11):2299-311.
Zhao P. et al “DNA vaccine of SARS-Cov S gene induces antibody response in mice”. Acta Biochim Biophys Sin (Shanghai). Jan. 2004;36(1):37-41. See marked p. 1-4.
Marra Ma et al “The Genome sequence of the SARS-associated coronavirus”. Science. May 30, 2003;300(5624):1399-404. Epub May 1, 2003.
Cavanagh D. “Severe acute respiratory syndrome vaccine development: experiences of vaccination against avian infectious bronchitis coronavirus”. Avian Pathol. Dec. 2003;32(6):567-82.

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