Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-05-16
2008-05-13
Campell, Bruce (Department: 1648)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S320100, C530S333000, C530S333000
Reexamination Certificate
active
07371837
ABSTRACT:
The present invention provides the complete genomic sequence of a novel human coronavirus, coined as human coronavirus-HKU1 (“CoV-HKU1”), isolated in Hong Kong. The virus belongs to the order Nidovirales of the family Coronaviridae, being a single-stranded RNA virus of positive polarity. Further study on nasopharyngeal aspirates from patients with community-acquired pneumonia has revealed that there are two genotypes, genotype A and genotype B, for this virus. In addition to the genomic sequences of these two genotypes, the invention provides the deduced amino acid sequences of the complete genome of the CoV-HKU1. The nucleotide sequences and deduced amino acid sequences of the CoV-HKU1 are useful in preventing, diagnosing and/or treating the infection by CoV-HKU1. Furthermore, the invention provides immunogenic and vaccine preparations using recombinant and chimeric forms as well as subunits of the CoV-HKU1 based on the nucleotide sequences and deduced amino acid sequences of the CoV-HKU1.
REFERENCES:
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Yount et al., “Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59”, Journal of Virology, vol. 76, No. 21, pp. 11065-11078 (Nov. 2002).
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Woo et al., “Phylogenetic and recombination analysis of coronavirus HKU1, a novel coronavirus from patients with pneumonia”, Arch Virol., vol. 150, pp. 2299-2311 (2005).
Chan Kwok Hung
Lau Kar Pui Susanna
Woo Chiu Yat Patrick
Yuen Kwok Yung
Campell Bruce
Dickstein & Shapiro LLP
Peng Bo
The University of Hong Kong
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